It appears that Zone of The Enders 3 is in development but from the looks of it Hideo Kojima may not be the one to finish the 3rd game in the series. In a recent KojiPro report it was mentioned how Kojima had been working on ZOE3 but the internal bandwidth at KojiPro is considered ”insufficient” for the project. Apparently Hideo Kojima wants someone else to take on the game. 
They made no mention of what platform ZOE 3 is in development for during the podcast but if Kojima is considering allowing external developers handle the game it’s likely in the early stages of development with current hardware in mind.
In the meantime, PS3, 360 and future PS Vita owners still have the Zone of the Enders HD collection to look forward to in 2012. Perhaps by then more details regarding Zone of the Enders 3 and who will be in charge of development will surface.
Source: Neogaf